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<h2>Types of Binary Relations</h2>

<table border=1 cellspacing=5 cellpadding=5>
<tr>
<th>Type</th>
<th style="width:100px">Description</th>
<th>Sample BioPAX Structure</th>
<th>Inferred Binary Relation(s)</th>
</tr>
<tr>
<td valign=center aling=center><b>controls-state-change-of</b></td>
<td valign=center aling=center>First protein controls a reaction that changes the state of the second protein.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-state-change-of-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/B-to-A.svg'/>
</tr>

<tr>
<td valign=center aling=center><b>controls-transport-of</b></td> 
<td valign=center aling=center>First protein controls a reaction that changes the cellular location of the second protein.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-transport-of-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/B-to-A.svg'/>
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<td valign=center aling=center><b>controls-phosphorylation-of</b></td> 
<td valign=center aling=center>First protein controls a reaction that changes the phosphorylation status of the second protein.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-phosphorylation-of-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/B-to-A.svg'/>
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<td valign=center aling=center><b>controls-expression-of</b></td> 
<td valign=center aling=center>First protein controls a conversion or a template reaction that changes expression of the second protein.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-expression-of-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/B-to-A.svg'/>
</tr>

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<td valign=center aling=center><b>catalysis-precedes</b></td>
<td valign=center aling=center>First protein controls a reaction whose output molecule is input to another reaction controled by the second protein.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/catalysis-precedes-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/A-to-B.svg'/>
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<td valign=center aling=center><b>in-complex-with</b></td> 
<td valign=center aling=center>Proteins are members of the same complex.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/in-complex-with-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/triangle.svg'/>
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<td valign=center aling=center><b>interacts-with</b></td> 
<td valign=center aling=center>Proteins are participants of the same MolecularInteraction.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/interacts-with-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/interacts-with-sif.svg'/>
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<td valign=center aling=center><b>neighbor-of</b></td> 
<td valign=center aling=center>Proteins are participants or controlers of the same interaction.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/neighbor-of-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/neighbor-of-sif.svg'/>
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<td valign=center aling=center><b>consumption-controled-by</b></td>
<td valign=center aling=center>The small molecule is consumed by a reaction that is controled by a protein</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/metabolic1-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/X-to-A.svg'/>
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<td valign=center aling=center><b>controls-production-of</b></td>
<td valign=center aling=center>The protein controls a reaction of which the small molecule is an output.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/metabolic1-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-production-of-sif.svg'/>
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<td valign=center aling=center><b>controls-transport-of-chemical</b></td>
<td valign=center aling=center>The protein controls a reaction that changes cellular location of the small molecule.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-transport-of-chemical-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/controls-transport-of-chemical-sif.svg'/>
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<td valign=center aling=center><b>chemical-affects</b></td>
<td valign=center aling=center>A small molecule has an effect on the protein state.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/chemical-affects-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/X-to-A.svg'/>
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<td valign=center aling=center><b>reacts-with</b></td>
<td valign=center aling=center>Small molecules are input to a biochemical reaction.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/metabolic2-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/reacts-with-sif.svg'/>
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<td valign=center aling=center><b>used-to-produce</b></td>
<td valign=center aling=center>A reaction consumes a small molecule to produce another small molecule.</td>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/metabolic2-biopax.svg'/>
<td valign=center align=center><img src='http://image.biopax-pattern.googlecode.com/hg/sif/used-to-produce-sif.svg'/>
</tr>

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<td valign=center>Legend:</td><td><img src='http://image.biopax-pattern.googlecode.com/hg/sif/legend.svg'/></td>
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